La nuova collana editoriale su CD-ROM per l'aggiornamento scientifico in campo diabetologico

Numero 1: Ridurre l'emoglobina glicata riduce il rischio cardiovascolare?
Contenuti

Introduzione

UGDP
A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes: mortality results.
Diabetes 19: 785-830, 1970

DCCT Research Group.
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
N Engl J Med. 329: 977-986, 1993
Link

Abraira C, Colwell JA, Nuttall FQ, et al.
Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes.
Diabetes Care 18:1113-23, 1995
Abstract

Malmberg K, Rydén L, Efendic S, et al.
Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI
study): effects on mortality at 1 year.
J Am Coll Cardiol 26: 57-65, 1995
Abstract

Ohkubo Y, Kishikawa H, Araki E, et al.
Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.
Diabetes Res Clin Pract 28: 103-117, 1995
Abstract

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).UK Prospective Diabetes Study (UKPDS) Group.
Lancet 352: 837-853, 1998
Abstract

Brownlee M.
Biochemistry and molecular cell biology of diabetic complications.
Nature 414: 813-820, 2001
Abstract

Selvin E, Marinopoulos S, Berkenblit G, et al.
Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus.
Ann Intern Med. 141: 421-431, 2004
Abstract

Nathan DM, Cleary PA, Backlund JY, et al.
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.
N Engl J Med 353: 2643-2653, 2005
Link

Malmberg K, Rydén L, Wedel H, et al.
DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity.
Eur Heart J 26:650-661, 2005
Link

Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, et al.
Effects of intensive glucose lowering in type 2 diabetes.
N Engl J Med 358: 2545-2559, 2008
Link

ADVANCE Collaborative Group, Patel A, MacMahon S, et al.
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
N Engl J Med 358: 2560-2572, 2008
Link

Premessa

Principles of Care & Guidelines for the Management Of Diabetes Mellitus.
NSW Department of Health, 1996.
Link

Asociacion Latinoamericana de Diabetes
Guidelines for the diagnosis, control and treatment of type 2 diabetes mellitus.
Rev Assoc Lat Diab 8 (suppl 1): 101-167, 2000.

National Institute for Clinical Excellence (NICE).
Management of type 2 diabetes - Managing blood glucose levels (Guideline G), 2002
Link a NICE

Canadian Diabetes Association. Clinical Practice Guidelines Expert Committee.
Pharmacologic management of type 2 diabetes.
Can J Diabetes 27 (suppl 2): S1-S152, 2003
Link

Asian-Pacific Type 2 Diabetes Policy Group.
Type 2 Diabetes. Practical targets and treatments, 2005
Link

International Diabetes Federation, Clinical Guidelines Taskforce, Global Guideline for Type 2 Diabetes, 2005
Link

American Diabetes Association
Clinical Practice Recommendations 2007
Diabetes Care 30: S4-S41, 2007
Link

Jellinger PS, Davidson JA, Blonde L, et al.
Road maps to achieve glycemic control in type 2 diabetes mellitus: ACE/AACE Diabetes Road Map Task Force.
Endocr Pract 13: 260-268, 2007
Link

Studi osservazionali

Moss SE, Klein R, Klein BE, Meuer SM.
The association of glycemia and cause-specific mortality in a diabetic population.
Arch Intern Med 154:2473-2479, 1994
Abstract

Muggeo M, Verlato G, Bonora E, et al.
Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study.
Circulation 96: 1750-1754, 1997
Link

Bjørnholt JV, Erikssen G, Aaser E, et al.
Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.
Diabetes Care 22:45-49, 1999
Link

Gerstein HC, Pais P, Pogue J, Yusuf S.
Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study.
J Am Coll Cardiol 33: 612-619, 1999
Link

Bonora E, Kiechl S, Oberhollenzer F, et al.
Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study.
Diabetologia 43:156-164, 2000
Link

Stratton IM, Adler AI, Neil HA, et al.
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study.
BMJ 321: 405-412, 2000
Link

DECODE Study Group, European Diabetes Epidemiology Group.
Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovascular diseases?
Diabetes Care 26: 688-696, 2003
Link

Khaw KT, Wareham N, Bingham S, et al.
Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk.
Ann Intern Med 141: 413-420, 2004
Link

Selvin E, Coresh J, Golden SH, et al.
Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study.
Arch Intern Med 165: 1910-1916, 2005
Link

Cavalot F, Petrelli A, Traversa M, et al.
Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study.
J Clin Endocrinol Metab 91: 813-819, 2006
Link

 

Studi sperimentali

Brownlee M.
Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001
Abstract

Rohlfing CL, Wiedmeyer HM, Little RR, et al.
Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial.
Diabetes Care 25:275-278, 2002
Link

Reusch JE.
Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?
J Clin Invest 112: 986-988, 2003
Link

McCarter RJ, Hempe JM, Gomez R, Chalew SA.
Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes.
Diabetes Care 27: 1259-1264, 2004
Link

Kilpatrick ES, Rigby AS, Atkin SL.
Mean blood glucose compared with HbA(1c) in the prediction of cardiovascular disease in patients with type 1 diabetes. Diabetologia 51: 365-371, 2008
Abstract

 

Studi di intervento

Principles of Care & Guidelines for the Management Of Diabetes Mellitus.
NSW Department of Health, 1996.
Link

Abraira C, Colwell J, Nuttall F, et al.
Cardiovascular events and correlates in the Veterans Affairs Diabetes Feasibility Trial. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes.
Arch Intern Med 157: 181-188, 1997
Abstract

UK Prospective Diabetes Study (UKPDS) Group.
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).
Lancet 352:837-853, 1998
Abstract

Asociacion Latinoamericana de Diabetes
Guidelines for the diagnosis, control and treatment of type 2 diabetes mellitus.
Rev Assoc Lat Diab 8 (suppl 1): 101-167, 2000.

Shichiri M, Kishikawa H, Ohkubo Y, Wake N.
Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients.
Diabetes Care 23 Suppl 2: B21-B29, 2000
Abstract

National Institute for Clinical Excellence (NICE).
Management of type 2 diabetes - Managing blood glucose levels (Guideline G), 2002
Link a NICE

Canadian Diabetes Association. Clinical Practice Guidelines Expert Committee.
Pharmacologic management of type 2 diabetes.
Can J Diabetes 27 (suppl 2): S1-S152, 2003
Link

Chiasson JL, Josse RG, Gomis R, et al.
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial.
JAMA 290: 486-494, 2003
Link

Gaede P, Vedel P, Larsen N, et al.
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.
N Engl J Med 348: 383-393, 2003
Link

Selvin E, Marinopoulos S, Berkenblit G, et al.
Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus.
Ann Intern Med. 141: 421-431, 2004
Abstract

Asian-Pacific Type 2 Diabetes Policy Group.
Type 2 Diabetes. Practical targets and treatments, 2005
Link

International Diabetes Federation, Clinical Guidelines Taskforce.
Global Guideline for Type 2 Diabetes, 2005
Link

Nathan DM, Cleary PA, Backlund JY,et al. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications
(DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353: 2643-2653, 2005
Link

Evans JM, Ogston SA, Emslie-Smith A, Morris AD.
Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin.
Diabetologia 49: 930-936, 2006
Link

Kronmal RA, Barzilay JI, Smith NL, et al.
Mortality in pharmacologically treated older adults with diabetes: the Cardiovascular Health Study, 1989-2001.
PLoS Med 3, 2006
Link

Stettler C, Allemann S, Jüni P, et al.
Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: Meta-analysis of randomized trials.
Am Heart J 152: 27-38, 2006
Abstract

American Diabetes Association, Clinical Practice Recommendations 2007
Diabetes Care 30: S4-S41, 2007
Link

Jellinger PS, Davidson JA, Blonde L, et al.
Road maps to achieve glycemic control in type 2 diabetes mellitus: ACE/AACE Diabetes Road Map Task Force.
Endocr Pract 13: 260-268, 2007
Link

National Institutes of Health, National Heart, Lung, and Blood Institute
Link1
Link2

 

Conclusioni

AMD - SID - Diabete Italia. Standard italiani per la cura del diabete mellito. Linee-guida e raccomandazioni, 2007
Link

 

 
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